Gene information
Official symbol CD40LG
Official full name CD40 ligand
Gene type protein-coding gene
ChromosomeXq26.3
Alias symbolCD40L; TRAP; gp39; hCD40L; CD154
Previous symbolHIGM1; IMD3; TNFSF5
Gene familyCD molecules; Tumor necrosis factor superfamily
Resources
Entrez Gene 959
HGNC HGNC:11935
Ensembl ENSG00000102245
Vega OTTHUMG00000022512
UCSC uc004faa.4
GO terms: 95 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002312 B cell activation involved in immune response GO Biological Processes -4.27715369 6 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002637 regulation of immunoglobulin production GO Biological Processes -8.47662495 11 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008047 enzyme activator activity GO Molecular Functions -1.49794348 13 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0019207 kinase regulator activity GO Molecular Functions -2.87704457 10 More
GO:0019209 kinase activator activity GO Molecular Functions -2.38668070 6 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0019887 protein kinase regulator activity GO Molecular Functions -2.69690139 9 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030183 B cell differentiation GO Biological Processes -4.52538214 9 More
GO:0030295 protein kinase activator activity GO Molecular Functions -2.50130986 6 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031295 T cell costimulation GO Biological Processes -2.15842877 6 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032735 positive regulation of interleukin-12 production GO Biological Processes -12.7826256 12 More
GO:0032813 tumor necrosis factor receptor superfamily binding GO Molecular Functions -5.47819787 7 More
GO:0032943 mononuclear cell proliferation GO Biological Processes -3.89391544 7 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042100 B cell proliferation GO Biological Processes -3.62199030 5 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042113 B cell activation GO Biological Processes -5.56585733 12 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046651 lymphocyte proliferation GO Biological Processes -3.08061793 6 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0070661 leukocyte proliferation GO Biological Processes -8.25401122 12 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04514 Cell adhesion molecules KEGG Pathway -5.33785320 11 More
hsa04672 Intestinal immune network for IgA production KEGG Pathway -7.87779205 9 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
hsa05330 Allograft rejection KEGG Pathway -10.3501019 10 More
hsa05416 Viral myocarditis KEGG Pathway -3.87607272 6 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 11 records
Drug name Interaction type Source PMID View
aldesleukin NCI 10841521 view
atorvastatin NCI 17064201 view
dapirolizumab pegol inhibitor ChemblInteractionsTTD view
fenofibrate NCI 14612213 view
imatinib NCI 16741250 view
lucatumumab TTD 23460534 view
pg-102 TTD view
rosiglitazone NCI 12695287 view
ruplizumab inhibitor ChemblInteractions view
selicrelumab TTD view
toralizumab inhibitor ChemblInteractions view
Related studies: 11 records
Molecular factor Omics type Application Objective MI type Reference
CD40 ligand proteomics ventricular fibrillation[prognosis (bad)] acute myocardial infarction Kalsch T et al. J Cardiovasc Electrophysiol. 2005
CD40 ligand proteomics adverse events[prognosis (bad)] ST elevation myocardial infarction Dominguez-Rodriguez A et al. Thromb Res. 2007
CD40 ligand proteomics high thrombus burden[prognosis (bad)] acute ST elevation myocardial infarction Youssef AA et al. Circ J. 2007
CD40 ligand proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tan J et al. Clin Cardiol. 2008
CD40 ligand proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Yoshioka T et al. Atherosclerosis. 2010
CD40 ligand proteomics medium predictor death[prognosis (bad)] acute ST elevation myocardial infarction Pusuroglu H et al. Coron Artery Dis. 2014
CD40 ligand proteomics no-reflow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Tascanov MB et al. Medicina (Kaunas). 2019
CD40 ligand proteomics depression[prognosis (bad)] myocardial infarction von Kanel R et al. Neuroimmunomodulation. 2010
CD40 ligand proteomics acute non-ST elevation myocardial infarction[diagnosis] acute non-ST elevation myocardial infarction Di Stefano R et al. Biomed Pharmacother. 2009
CD40 ligand proteomics myocardial infarction[diagnosis] myocardial infarction Cangemi R et al. J Am Coll Cardiol. 2014
CD40 ligand proteomics thrombosis[prognosis (bad)] ST elevation myocardial infarction Dominguez-Rodriguez A et al. Int J Med Sci. 2016
All rights reserved: Soochow University Center for Systems Biology